Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract

Background/Objectives: Male androgenetic alopecia (AGA) is a common hair problem. Serenoa repens extract has been shown to inhibit both types of 5-α reductase and, when taken orally, has been shown to increase hair growth in AGA patients. The aim of this study was to assess the efficacy of topical products containing S. repens extract for the treatment of male AGA. Methods: This was a pilot, prospective, open, within-subject comparison limited to 24 weeks using no placebo controls. In all, 50 male volunteers aged between 20 and 50 years received topical S. repens products for 24 weeks. The primary end-point was a hair count in an area of 2.54 cm2 at week 24. Secondary end-points included hair restoration, investigator's photographic assessment, patients’ evaluation and discovering adverse events. Results: The average hair count and terminal hair count increased at weeks 12 and 24 compared to baseline. Some of these positive results levelled off at week 24, presumably because the concentrated topical product containing S. repens extract was stopped after 4 weeks. The patients were satisfied with the products and the side-effects were limited.

วารสาร : Australas J Dermatol. 2016 Aug;57(3):e76-82

Keyword : 5-alpha reductase; Biothymus-M; Canfield; Serenoa repens; androgenetic alopecia treatment; male pattern baldness treatment.